neoformans, highlighting the importance of monitoring the emergence of new fungal pathogens for which thermotolerance may be an important transitional step towards pathogenesis in humans. liquefaciens have strikingly similar ultrastructural and biological properties to those of C. We conclude that polysaccharides of the environmental yeast C. liquefaciens PS could not protect mice against infection with C. neoformans led to complete lethality of G. PS from both species had indistinguishable effects on phagocytosis levels, NO production and the secretion of a variety of immune mediators. Ultrastructural analysis by high-resolution microscopy showed that both species produce large and complex capsules. liquefaciens, and yeast pathogenicity to an invertebrate host, in comparison with C. Here, we examined the ultrastructure and biological activity of capsular and secreted PS from C. Previously, we showed that both species produce PS of similar composition. The main Cryptococcus virulence factor is the production and secretion of polysaccharides (PS). liquefaciens, have been observed recently. Although Cryptococcus neoformans and Cryptococcus gattii are the main agents of human cryptococcosis, opportunistic infections by environmental species, such as C. Invasive fungal infections, including cryptococcosis, are a growing threat to immunocompromised patients.
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